Ventrículo Único

Valor pronóstico del NT-proBNP en adultos con cirugía de Fontan

Valor pronóstico del NT-proBNP en adultos con cirugía de Fontan

Este artículo , publicado en CJC Pediatric and Congenital Heart Disease (2026), analiza el valor pronóstico del NT-proBNP en una cohorte de 369 adultos con paliación de Fontan seguidos durante una mediana de 4.8 años. El estudio concluye que el NT-proBNP es una herramienta superior o comparable a los métodos de evaluación convencionales para predecir el riesgo de muerte o trasplante . A continuación, se resumen los hallazgos fundamentales y los puntos que deberían modificar la práctica clínica actual: Correlatos Clínicos y Hemodinámicos Los niveles elevados de NT-proBNP no son solo marcadores de insuficiencia cardíaca, sino que reflejan fallos multisistémicos en la fisiología de Fontan. Se asocian significativamente con: Factores quirúrgicos: Conexiones atriopulmonares y mayor edad al momento de la cirugía de Fontan. Comorbilidades: Fibrilación auricular, disfunción hepatorrenal (puntuación MELD-XI elevada) y enfermedad renal crónica. Hemodinámica e Imagen: Dilatación del ventrículo sistémico…

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